Titlebook: Label-Free Biosensor Methods in Drug Discovery; Ye Fang Book 2015 Springer Science+Business Media New York 2015 Biotechnology.Cell signali

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Surface Plasmon Resonance for Therapeutic Antibody Characterizationibodies, owing to its ability to real-time analyze interactions of an antigen with an antibody without intrinsic or extrinsic labels. SPR has been a mainstay in pharmaceutical companies for almost two decades, and its role in drug discovery has experienced significant growth with the expanded number

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Label-Free Cell-Based Biosensor Methods in Drug Toxicology Analysisthe intracellular and extracellular microenvironment conditions, physiological parameters and responses of cells upon stimulation. Because of their advantages associated with long-term recording in a noninvasive way, fast response time, and label-free experimentation, these biosensors have been wide

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Silicon Photonic Micro-Ring Resonators for Drug Screening and Kinetic Analysis sample. We present here the system applied to multiplex detection of antibodies in serum, the detection of receptor–ligand interactions, and the kinetic characterization of binding. The core of the technology is a silicon microchip, on the surface of which we pattern 128 microscopic ring resonators

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Optical Waveguide Light-Mode Spectroscopy for Ion Channel Profilingns-channel ion transport, and allow further development in utilization of ion channels as models for pharmacological purposes (drug design targeting ion channels or diagnostic applications in clinical trials). This chapter describes a sensor setup for supported cell-derived membrane fragments deposi

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Label-Free Profiling of Endogenous Receptor Responses in Primary Isolated Cardiac Cellsmulation. While a vast majority of studies have investigated signaling responses in cell lines stably expressing a receptor of interest, relatively fewer studies have used label-free technology to examine endogenous receptor responses in primary cells with more physiologic relevance. The exploration

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Surface Plasmon Resonance to Study Cell Signaling and GPCR Functional Selectivity in Live Cellsble label-free method to monitor live cell responses in real time. In contrast to molecular and biochemical assays, which rely on the detection of a unique marker such as cAMP, protein phosphorylation, or intracellular calcium, SPR is capable to detect and follow cell responses integrating the modul

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