Titlebook: Jak-Stat Signaling : From Basics to Disease; Thomas Decker,Mathias Müller Book 2012 Springer-Verlag Wien 2012 Cell Differentiation.Hematop

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Minuet

揭穿真相

Evolution of Jak and Stat Proteins,the signaling pathway in general. We then oppose the simply structured pathway in . to the more complex situation in mammals. Furthermore, we compare the Jak-Stat system between mammals and teleost fishes. Finally, we move to the less well investigated roles of Stats in the worm . and the slime mold

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absolve

JAK/STAT Signaling and Invertebrate Immune Responses,n the model organism .. However, we tentatively cover available information on JAK/STAT signaling in other invertebrates, including mosquitoes. Covered topics include the components of JAK/STAT signaling and their role in humoral, cellular and mucosal immunity. Finally, we summarize recent developme

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Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development,ions of Stat5a and Stat5b genes to the generation of hematopoietic cells and to their malignant transformation are subject of the following review. Absence of Stat5 proteins causes lymphopenia and Stat5 was recognized to be indispensable for the development of B-, T- and NK-cells. The few peripheral

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Regulation of Dendritic Cell Development by STATs, activating adaptive immune cell types. Delineating the molecular control of DC development will provide important information about the generation of natural immunity as well as approaches to regulate DCs in clinical settings. DCs are generated from hematopoietic stem cells through specialized prog

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STAT Transcription Factors: Controlling All Aspects of NK Cell Biology,l decades NK cells have been portrayed as first line defense against virally infected and malignant cells. But recent reports unraveled far more diverse properties of NK cells, e.g. their involvement in reproductive immunology and in mucosal defense of pathogens in the gut, and especially their abil

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Function of JAKs and STATs in Lymphocytes: Bench to Bedside,ammalian genome, each with unique functions in immune cells. Consistent with studies in mice, genetic evidence in humans has strongly linked the JAK/STAT pathway to primary immunodeficiencies, infection, autoimmunity and cancers. The following chapter will discuss the key role played by JAKs and STA

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The Role of Janus Kinases in Hematopoietic Malignancies,activity causes various hematological phenotypes associated with overproduction of terminally differentiated cells and/or blastic transformation. Here we review the somatic mutations in the Janus family kinases and the associated hematological phenotypes.