Titlebook: Intracellular Traffic and Neurodegenerative Disorders; Peter H. St. George-Hyslop,William C. C. Mobley,Yv Book 2009 Springer-Verlag Berlin

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,Axonal Transport of Neurotrophic Signals: An Achilles’ Heel for Neurodegeneration?,d cognitive failure and understanding of the underlying mechanisms. Given the marked similarities in pathological and clinical phenotypes between Alzheimer‘s disease and Down syndrome, studies of the pathogenesis of one can be expected to complement and support those in the other. Alzheimer‘s diseas

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,Huntington’s Disease: Function and Dysfunction of Huntingtin in Axonal Transport,uses Huntington‘s disease is an abnormal polyglutamine (polyQ) expansion in the huntingtin protein. One key, early pathogenic event in the disease is the alteration of axonal transport. This alteration is linked, at least in part, to a defect in huntingtin function in transport. Huntingtin is found

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The Role of Retromer in Neurodegenerative Disease,e proteins with diverse physiological functions. The receptors that mediate sorting of lysosomal hydrolases at the Golgi traffic rapidly between the Golgi and endosomes to deliver newly synthesised hydrolases to a pre-lysosomal endosome before returning to the Golgi to repeat the process. The misloc

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Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role king and endocytosis regulate the function of various receptors, channels and transporters in neurons, and deregulation of the ubiquitination system is associated with neurode-generative diseases. Hence, we will focus on recent advances in understanding the mechanisms and functional roles of ubiquit

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Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA,ep that determines APP processing fates and is likely to play a role in pathological processes leading to Alzheimer‘s disease (AD). SORLA is a member of a novel class of intracellular sorting proteins and acts as a neuronal receptor for APP, controlling transport and proteolytic processing of the pr

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0945-6066 y be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated..978-3-642-09972-4978-3-540-87941-1Series ISSN 0945-6066 Series E-ISSN 2196-310X

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Sam Gandy,Odete da Cruz e Silva,Edgar da Cruz e Silva,Toshiharu Suzuki,Michelle Ehrlich,Scott Smallency caused by material properties, and it is still used today by some systems. This approach was soon supplemented by single frequency phase measurements, in order to avoid distortion978-3-642-06072-4978-3-540-26491-0