Titlebook: Intestinal Tumorigenesis; Mechanisms of Develo Vincent W. Yang,Agnieszka B. Bialkowska Book 2015 Springer International Publishing Switzerl

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E. Gabriela Chiorean,Andrew Coveler,Jon Grim,William M. Grady MDconsidered, and many of the basic theories are revised in detail and even in general. The body of information had to be limited as it was not advisable to increase the volume of the book. In particular, no attempt was made to cover all of the practical applications. They appear as examples following

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Microsatellite Instability and Intestinal Tumorigenesis,h repair, genetic versus sporadic microsatellite instability, methods of testing for microsatellite instability, and the clinical implications of microsatellite instability in the large bowel, small bowel and stomach.

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The Epigenetics in Intestinal Tumorigenesis,ostic and predictive biomarkers in human colorectal cancer. This article reviews the current state of literature in the field, and focuses on the clinical relevance of various epigenetic alterations as potential biomarkers for the personalized treatment of patients suffering from this common malignancy worldwide.

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Inflammation and Colorectal Cancer, CAC as a model system. We have also explored some of the promising strategies for preventing progression of inflammation to colon cancer. The emerging role of dietary factors, obesity and gut microbiota in colon cancer is also reviewed.

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Sphingolipids in Intestinal Inflammation and Tumorigenesis,ds are ceramide, sphingosine, and sphingosine-1-phosphate. These sphingolipids and their synthetic enzymes have been extensively implicated in intestinal inflammation and tumorigenesis and will be the focus of this chapter.

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The Role of PI3K Signaling Pathway in Intestinal Tumorigenesis,ing mechanisms we have opportunities to exploit multiple sites of the cascade, and develop targeted inhibitors against these small molecules. A thorough understanding of this pathway and its signaling mechanisms is paramount to the development of new and improved treatments for intestinal cancers.

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Targeted Therapies For Intestinal Tumorigenesis,s, although many other promising targeted therapies are in early phase clinical studies. An emerging area in the management of colorectal cancer is immunotherapy. In this chapter, we highlight some of the areas of novel therapy development, notably signal pathway targeted therapies and tumor immunotherapy.