Titlebook: Immunopathology in Toxicology and Drug Development; Volume 1, Immunobiol George A. Parker Book 2017 Springer International Publishing AG 20

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Josely F. Figueiredo,Kirstin F. Barnhart,Niraj Tripathi

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Basic Immunobiology,overview of the salient immunologic concepts, structures, cells and physiologic processes. Current review-type references are provided for further insight into the various components of this immense topic.

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Cells of the Immune System,mmune system cells is critical to understanding immunological responses, particularly those immunological responses that are commonly encountered in non-clinical toxicology studies. Histopathological evaluation of tissue specimens is a major component of the analysis of non-clinical toxicology studi

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Development of Immune System Organs,ent misinterpretation of these normal changes as xenobiotic-associated. This chapter is focused on histomorphological rather than physiological alterations, though the intent certainly is not to dismiss the importance of traditional immunological assays in the detection of xenobiotic-associated infl

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GREG

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Enhanced Immunohistopathology, affected and also provide clues on the possible mechanism of action of the test article. This methodology is used with short term studies in conjunction with gross changes, body weights, organ weights, clinical chemistry and hematological measurements and may be a part of a larger immunotoxicity pr

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The Murine Local Lymph Node Assay,e. The contact allergenic potential of a compound is evaluated by the cellular proliferation of the draining lymph nodes of mice following topical treatment of the ear flap with test compound. This stimulation reflects the induction of an immune response. The LLNA utilizes three concentrations allow