Titlebook: Immunopathology in Toxicology and Drug Development; Volume 1, Immunobiol George A. Parker Book 2017 Springer International Publishing AG 20

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Cells of the Immune System,t have secondary immunological functions. These subcategories are convenient for purposes of discussion, but extensive observations indicate there are many overlaps between cells of the various subcategories. Macrophages, in particular, occupy a functional space that is shared between the innate and

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Signaling and Effector Molecules in Immunity, molecules, all supported by a stromal framework that may provide additional immunomodulatory signals. Signaling and effector molecules of the immune system have been the focus of intense investigation in recent decades, resulting in a massive accumulation of relevant information. The aim of this ch

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Development of Immune System Organs,cology studies, in juvenile toxicology studies the pathologist and toxicologist must also be concerned with the influence of normal postnatal development on the histologic appearance and functional attributes of immune system tissues. In addition to direct age-related differences in histomorphology,

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Aging of Immune System Organs,due to structural alterations in immune system organs or depletion of immunocyte populations. However, other age-related alterations involve dysregulation and failures in coordination of various immunological functions. Aging effects on the innate immune system may result in a pro-inflammatory statu

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Flow Cytometry and Immunophenotyping in Drug Development,mune system alterations. Flow cytometry is an important tool that can be applied throughout drug development (e.g. early discovery to clinical monitoring) to evaluate immunobiological and immunotoxicological alterations resultant from therapies. Traditionally, flow cytometry has broad applications i

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Clinical Pathology Assays in Immunopathology, response to administration or withdrawal of a test item. A variety of assays can be performed in a clinical pathology laboratory with body fluids using either clinical pathology analyzers or other instruments. Information from the basic assays in clinical pathology, including hematology, clinical c

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Application of Immunohistochemistry in Toxicologic Pathology of the Hematolymphoid System,hat is routinely collected for toxicologic pathology assessment. This chapter will address which antigen markers are best used for assessing toxicologic effects in the hematolymphoid system and for diagnosing hematolymphoid neoplasms in FFPE tissues from mice and rats. These markers can be normally