Titlebook: Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunolog; Bruce Beutler Book 2008 The Editor(s

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Fevers, Genes, and Innate Immunityce of these conditions and facilitated the subsequent identification of causative gene mutations. The prototype autoinflammatory syndrome, familial Mediterranean fever, is characterized by self-limiting episodes of localized inflammation. Hallmarks of the classical autoimmune response are largely ab

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Mice: The Identification of a New Pathway for the Development of Autoimmunityve autoimmune disease that proves lethal beginning at 6 months of age. Numerous targets of Itch-mediated ubiquitination have been identified, and some of these have defined physiological roles for Itch signaling in T cell anergy and T cell differentiation. Studies of . mice have also allowed for the

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