Titlebook: Hydrogen Sulfide in Kidney Diseases; A Novel Pharmacother George J. Dugbartey,Alp Sener Book 2023 The Editor(s) (if applicable) and The Aut

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George J. Dugbartey,Hjalmar R. Bouma,Manujendra N. Saha,Ian Lobb,Robert H. Henning,Alp Sener in invertebrate animals, but the occurrence of such homotypic clusters of TFBSs (HCTs) in the human genome has remained largely unknown. To explore whether HCTs are also common in human and other vertebrates, we used known binding motifs for vertebrate TFs and a hidden Markov model-based approach t

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George J. Dugbartey,Max Y. Zhang,Alp Senerne families and the evolution of those gene families inside a species tree, represents one of the most powerful computational techniques for reconstructing detailed histories of domain and gene family evolution in eukaryotic species. However, the DGS reconciliation framework allows for the reconcili

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xt mining methods extract annotations from existing unstructured data descriptions and often provide inaccurate output that requires manual curation. Automatic data-based augmentation (generation of annotations on the base of expression data) can considerably improve the annotation quality and has n

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Hydrogen Sulfide and the Renal System,cially among industrial workers. This is due to its ability to reversibly inhibit the activity of cytochrome . oxidase, a terminal enzyme of the mitochondrial electron transport chain. Recently, however, H.S has risen above its notorious public image and is now seen by researchers as an endogenously

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Hydrogen Sulfide for Cisplatin- and Gentamicin-Induced Acute Kidney Injury,dney injury (AKI) is a major side effect of cisplatin therapy. While the antineoplastic action of cisplatin is due to formation of cisplatin-DNA cross-links, which damage rapidly dividing cancer cells upon binding to DNA, its nephrotoxic effect results from metabolic conversion of cisplatin into a n

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Hydrogen Sulfide for Diabetic Kidney Disease and Focal Segmental Glomerulosclerosis,rbidity and mortality among the diabetic population despite optimal management. Its clinical hallmark includes persistent hyperglycemia, hypercreatininemia, uremia, sustained albuminuria, renal hemodynamic changes, and elevated blood pressure. Histologically, DKD presents with excessive accumulation

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Hydrogen Sulfide for the Treatment of Hypertensive Nephropathy and Calcium-Based Nephrolithiasis,act on renal function. Uncontrolled hypertension causes chronic kidney disease, which progresses to end-stage renal disease and eventually loss of renal function. Unfortunately, the mechanism underlying the pathogenesis of hypertension and its associated nephropathy is still poorly understood. Also