Titlebook: Heat Shock Factor; Akira Nakai Book 2016 Springer Japan 2016 Heat shock.Protein homeostasis.Proteostasis.Heat shock response.HSF.Heat shoc

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高談闊論

HSF Maintains Sensory Organs Members of this family are involved in development of some tissues such as the brain and reproductive organs. In addition, they are involved in development of the lens and olfactory epithelium, which are originated from the sensory placodes. Analysis of these sensory organs reveals that HSF activit

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HSF Is Required for Gametogenesis, especially HSF1 and HSF2, play important roles during this process in cell type- and stage-specific manners; however, their functions in spermatogenesis and oogenesis are different because the cellular kinetics of spermatogenesis and oogenesis are completely different. Basically, HSF1 acts in cyto

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GNAW

Heat Shock Factors Modulate Circadian Rhythmshavior, hormone release, metabolism, and so on. Even in homeothermic mammals, body temperature fluctuates in a circadian manner that transmits the time information to peripheral tissues and cells. The body temperature rhythms cause cyclic activation of the transcription factor HSF1 and its targets s

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HSF Inhibits the Progression of Age-Related Neurodegenerative Diseasesare refractory conditions that appear during the prime of life. The heat shock factor (HSF)–heat shock protein (HSP) pathway, which controls and facilitates physiological protein homeostasis, may hold the key to understanding the neurodegenerative process. In this chapter, we describe the clinical a

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HSF and Heart Diseasess the activation of heat shock proteins and plays a protective role against different pathological stimuli. HSF1 is activated by phosphorylation and transferred into the nucleus. HSPs also regulate HSF1 activity. HSF1 activity is required to maintain redox state and attenuate oxidative damage in the

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HSF Supports Cancerthese, HSF1 is the most well studied and is the master transcriptional regulator of cellular responses to not only heat but also a wide variety of other stressors. During the progression of many types of cancer, HSF1 becomes co-opted by mechanisms that are evidently triggered in the emerging tumor c

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HSF1 Activation by Small Chemical Compounds for the Treatment of Neurodegenerative Diseases, such as heat shock stress and oxidative stress, which induces the expression of various molecular chaperones. HSF1-induced molecular chaperones, including heat shock protein 40 (Hsp40) and Hsp70, suppress protein misfolding through binding to structurally unstable proteins and thereby protect cell

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