Titlebook: Heat Shock Factor; Akira Nakai Book 2016 Springer Japan 2016 Heat shock.Protein homeostasis.Proteostasis.Heat shock response.HSF.Heat shoc

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Proteostasis and Adaptation to High Temperature Stresscapacity is regulated in cells. Furthermore, it discusses the fundamental function of the heat shock response, which is required for adaptation in all organisms, including those living in extreme high-temperature environments.

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HSF Modulates Neural Development Under Normal and Stress Conditionsatric disorders. In this chapter, we summarize the roles of HSFs in both normal and pathological brain development with a primary focus on the cerebral cortex and discuss potential mechanisms governing the multifaceted roles of HSFs under both normal and pathological conditions.

Organization

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HSF1 Activation by Small Chemical Compounds for the Treatment of Neurodegenerative Diseasesfact, many compounds that activate HSF1 have been tested for their potential as therapeutic agents against neurodegenerative diseases. In this chapter, we introduce various HSF1-activating compounds, their mechanisms of activation of HSF1, and their therapeutic effects against neurodegenerative diseases.

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HSF Maintains Sensory Organs organ derived from the sensory placodes, and its adaptation to acoustic trauma is highly dependent on HSF1. In this chapter, we summarize roles of HSF family members in the sensory organs and discuss about molecular mechanisms of development and maintenance by the HSF family members.

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Book 2016ecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evo

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rmopaare Verwendung finden. Einen Schwerpunkt bilden dabei die refrakt?ren Materialien. Da nicht nur die Einsatztemperaturgrenzen sich nach oben verschieben, sondern auch die mechanischen Belastungen (z. B. 500 … 800 K/s Temperaturwechsel), wurden eine Reihe von mechanischen Kennwerten bei 1000 °C r