Titlebook: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design; A Review of 20 Years Marc H V Van Regenmortel Book 2019 Springer Nature Switzer

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Reductionism and Complexity in Molecular Biology: Scientists Now Have the Tools to Unravel Biologica early days of molecular biology—underestimates this complexity and therefore has an increasingly detrimental influence on many areas of biomedical research, including drug discovery and vaccine development.

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What Is a B Cell Epitopes, and mimotopes. All epitopes have fuzzy boundaries and can be identified only by their ability to bind to certain antibodies. Antigenic cross-reactivity is a common phenomenon because antibodies are always able to recognize a considerable number of related epitopes. This places severe limits to th

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Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Rey molecular design strategies to the development of peptide-based vaccines. The stated aim is to transform the development of a vaccine from a trial and error empirical operation into a so-called rational, structure-based process. In the present review, it is argued that it is misleading to oppose r

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Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopesadopt the structures observed when epitopes of pathogens are bound to neutralizing antibodies. Although more than a thousand synthetic peptides have been examined as potential prophylactic vaccines, only 125 peptides have progressed to phase I clinical trials, 30 have made it to phase II trials but

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Specificity, Polyspecificity and Heterospecificity of Antibody-Antigen Recognitionbody specificity was attributed to sequence differences in complementarity-determining regions (CDRs) but as increasing numbers of crystallographic antibody-antigen complexes were elucidated, specificity was analyzed in terms of six antigen-binding regions (ABRs) that only roughly correspond to CDRs

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Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionismng number of biologists have become critical of the reductionist view that biological systems can be fully explained by the physico-chemical properties of their constituent parts. Biology is increasingly regarded as an autonomous discipline requiring its own explanatory concepts not found in chemist

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The Rational Design of Biological Complexity: A Deceptive Metaphorim implies that their knowledge of the innumerable causal connections present in biological systems is sufficient to allow them to deduce and predict the outcome of their experimental interventions. The design metaphor is shown to originate in human intentionality and in the anthropomorphic fallacy