Titlebook: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design; A Review of 20 Years Marc H V Van Regenmortel Book 2019 Springer Nature Switzer

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https://doi.org/10.1007/978-4-431-56478-2d to several different epitopes. It is concluded that only trial and error, empirical investigations using numerous immunization protocols may eventually allow us to identify which mixtures of immunogens are likely to be the best candidates for an HIV-1 vaccine.

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https://doi.org/10.1007/978-90-6704-927-6annot be expected to be present in identical form in the host to be vaccinated. It is possible to rationally design and optimize an epitope to fit one particular antibody molecule or to improve the paratope binding efficacy of a monoclonal antibody intended for passive immunotherapy. What is not pos

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Marc H V Van RegenmortelProvides a broad overview to the attempts to design a preventive HIV vaccine.Broadens the understanding of reasons for the failure to develop a preventive HIV vaccine.Includes numerous critical commen

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Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Sciencentists are no longer aware of the empirical foundations of all experimental science. This is evident from published statements that claim, for instance, that rational design represents “the only approach that can elevate vaccine research from an empirical exercise to a scientific discipline” (Karlsson-Hedestam et al. 2008).