Titlebook: Glial Cells in Health and Disease of the CNS; Rommy von Bernhardi Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusi

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Oligodendrocytes: Functioning in a Delicate Balance Between High Metabolic Requirements and Oxidativlucidation of the role of astrocytes in tripartite synapses (Tsacopoulos and Magistretti in J Neurosci 16:877–885, .). Still, unlike astrocytes, rich in cytochrome-P450 and other anti-oxidative defense mechanisms (Minn et al. in Brain Res Brain Res Rev 16:65–82, .; Wilson in Can J Physiol Pharmacol.

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Astrocyte Dysfunction in Developmental Neurometabolic Diseasesperate to maintain the balance needed for normal development. Here, we review the alterations in astrocyte functions that contribute to a variety of developmental neurometabolic disorders and provide additional data on the predominant role of astrocyte dysfunction in the neurometabolic neurodegenera

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Microglia in Cancer: For Good or for Bad?herapies, such as surgery, radio- and chemotherapy, the outcome for patients with glioblastoma is nearly always fatal. The glioblastoma microenvironment has a tremendous influence over the tumor growth and spread. Microglia and macrophages are abundant cells in the tumor mass. Increasing evidence in

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Peripheral Inflammation and Demyelinating Diseasesiterature that demonstrates a clear but complex relationship between the central nervous system (CNS) and the immunological system, both under . or pathological conditions. In diseased brains, peripheral inflammation can transform “primed” microglia into an “active” state, which can trigger stronger

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Regulation of Oligodendrocyte Differentiation and Myelination by Nuclear Receptors: Role in Neurodegnscription factors are master regulators of gene expression. Here, we present an overview of the role of nuclear receptors and their selective pharmacological modulators in oligodendrocytes linage, their role in myelination and remyelination and their potential use as a therapeutic strategy for demy

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The Role of Galectin-3: From Oligodendroglial Differentiation and Myelination to Demyelination and Rnction, promotes oligodendroglial cell differentiation, and regulates microglial responses to limit cuprizone- (CPZ)-induced demyelination and foster remyelination. In this study, 8-week-old Gal-3-deficient (..) and wild type (WT) mice were fed a diet containing 0.2?% CPZ w/w for 6?weeks, after whic

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