Titlebook: Genomic Elements in Health, Disease and Evolution; Junk DNA Kyriacos Felekkis,Konstantinos Voskarides Book 2015 Springer Science+Business M

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,Diabetes and Alzheimer’s Disease,in embryonic stem cells but also in somatic cells indicating their role in gene expression during cellular differentiation and cell type determination. CpG islands, therefore illustrate the complex role played by DNA methylation in the regulation of transcription.

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between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all 978-1-4939-4365-4978-1-4939-3070-8

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these elements their role in disease and evolution.This bookOver 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this

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Long Non-coding RNA,t-transcriptional levels. They also take a part in various physiological and pathological processes, participating in cell development, immunity, disease processes and oncogenesis..Here I discuss and summarize, current knowledge about lncRNA origin, function and involvement in human disease.

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Copy Number Variation in Human Health, Disease and Evolution,both coding and junk DNA. Importantly CNV are important contributors to non-pathogenic and pathogenic variability between individuals. In this chapter we discuss the mechanisms of formation of CNV, the evolutionary forces acting on CNV, methods for their detection and evaluation, and their contribution to normal and pathogenic human variability.

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