| 書目名稱 | Genomic Elements in Health, Disease and Evolution | | 副標(biāo)題 | Junk DNA | | 編輯 | Kyriacos Felekkis,Konstantinos Voskarides | | 視頻video | http://file.papertrans.cn/383/382893/382893.mp4 | | 概述 | Includes information and novel functions about all the known genomic elements in a single publication.Discusses the physiologic function of these elements their role in disease and evolution.This book | | 圖書封面 |  | | 描述 | Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book,?the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all | | 出版日期 | Book 2015 | | 關(guān)鍵詞 | copy number variations; miRNA genes; miRNA targets; natural selection; non-coding sequences; transposons | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4939-3070-8 | | isbn_softcover | 978-1-4939-4365-4 | | isbn_ebook | 978-1-4939-3070-8 | | copyright | Springer Science+Business Media New York 2015 |
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