Titlebook: Genetics and Alzheimer’s Disease; Colloque Medecine et Pierre Marie Sinet,Yvon Lamour,Yves Christen Conference proceedings 1988 Springer-Ve

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Alfred Bellebaum,Robert Hettlagend neurofibrillary tangles. The sequence of several tau monoclonal antibody recognition sites has been identified and demonstrates that large portions of the tau molecule are included in the neurofibrillary tangle.

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,Extended Kindreds as a Model for Research on Alzheimer’s Disease,narrow confidence limits from large bias-free pedigrees; these are the only ones for which Mendelian dominant autosomal transmission, to the exclusion of environmental effects, has been established. Large pedigrees have been decisive in recent progress in the molecular genetics of Alzheimer’s diseas

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grotto

,Dermatoglyphic Patterns in Senile Dementia of Alzheimer’s Type,alue of this index was also significantly more frequent in the SDAT group than in the two other groups (P < 0.02), as was an index of transversality higher than 31 on at least one hand (P < 0.01)..In contrast with other reports, we have not found significantly different frequencies of digital ulnar

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,Trisomic and Transgenic Mice in the Study of the Pathogenesis of Alzheimer’s Disease and Down’s Synde direct injury to the nervous system as the result of increased activity of one or a few genes, as well as indirect effects brought about by abnormalities in the development of the trisomic nervous system or by increased susceptibility to injurious agents. Several model systems for studying these

Solace

,Precursor of Alzheimer’s Disease (PAD) A4 Amyloid Protein,We also suggest that if amyloid deposition occurs at clinical target sites, such as in neurons or between synapses, amyloid formation could be a crucial event for the clinical expression of dementia..The localization of the amyloid precursor in rat brain at or near the surface of neurons is in agree

BARGE

,Cloning of the Beta Amyloid Peptide Gene in Alzheimer’s Disease,n cDNA libraries constructed from three patients with AD, we never observed the insertion of 168 bp between position 865 and 866 which has been recently reported in cultured cells. This suggests that even if different populations of BAPP mRNA are present in normal and AD brain, as a result of an alt

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,Molecular Analysis of Patients with Alzheimer’s Disease, potentially interesting to study chromosome 21 gene expression in AD. RNA quantification experiments were run on fibroblast cultures from five AD patients, three age-matched controls and two DS patients: mRNA for CuZn superoxide dismutase was significantly increased in four AD patients and two DS p

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Culmination