Titlebook: Gene Transfer and Therapy in the Nervous System; Fred H. Gage,Yves Christen Conference proceedings 1992 Springer-Verlag Berlin Heidelberg

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Manfred Wick,Wulf Pinggera,Paul Lehmannders are a result of defective gene expression and can be corrected by application of modern molecular approaches. The ultimate success of this strategy requires a detailed understanding of normal gene expression in the nervous system. In the case of Parkinson’s disease (Fig. 1b), the primary therap

ciliary-body

Preparation and control of serum albumin, of one or more human CuZnSOD transgenes into the mouse genome. Although physically normal, these transgenic mice exhibit several differences from control mice when exposed to known or presumed forms of oxidative stress. After a 30-second cold injury to the cerebral cortex, transgenic mice with appr

Somber

Sickle-cell Disease and Vascular Occlusionstranded DNA virus has a large genome (150 kb) which may carry up to 50 kb of foreign DNA at replaceable sites. This virus has a number of advantages for delivery of genes to neurons. It can be taken up by nerve terminals and transported by rapid retrograde transport to the cell nucleus; it can be p

Exclaim

Signal-averaged surface electrocardiography,ons, the virus replicates primarily in skin or mucosal epithelial cells prior to entering regional axon terminals and retrograde transport of the virus capsid to sensory ganglia, where it may either replicate or establish latency (Roizman and Sears 1990; Fig. 1). Latent virus can be reactivated by a

舊式步槍

Clinical Aspects of Electroporationoximately two thirds of DMD patients carry detectable deletions in the gene encoding dystrophin (Walker et al. 1989; Koenig et al. 1987), which is a muscle cytoskeletal protein (Koenig et al. 1988). Dystrophin protein (Hoffmann et al. 1988) and transcript (Oronzi Scott et al. 1988) are either absent

aggravate

https://doi.org/10.1007/978-1-4615-7237-4rstanding of the conditions required for efficient gene transfer and subsequent stable expression. A 14 kilobase mouse dystrophin cDNA was cloned by splicing together two overlapping partial cDNA constructs at a unique . I restriction site. The clone was full-length, as determined by selective seque

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Clinical Aspects of Inner Ear Deafnesst, been established. In the present study, we grafted cell lines expressing form I of human tyrosine hydroxylase after infection with a recombinant retrovirus and selection in tyrosine-free-medium to dopamine (DA) denervated striatum. Our goal was to analyse the extent to which extracellular DA leve

strain

Ornament

Clinical Aspects of Neutron Capture Therapygenes. Both human NF-L and NF-H genes are expressed in a tissue-specific fashion in transgenic mice. For the NF-L gene, various constructs have been tested in transgenic mice to define regulatory regions contributing to neuronal expression. Unexpectedly, this analysis demonstrated the presence of in

reperfusion

Lowell S. Young,Robert H. Rubin As importantly, nerve growth factor is needed to induce and promote the regeneration of lesioned axons. Regardless of the cellular or extracellular substrates used by these regrowing axons, the availability of nerve growth factor is a minimum requirement for successful regeneration of adult perturbed axons.