Titlebook: Gene Transfer and Therapy in the Nervous System; Fred H. Gage,Yves Christen Conference proceedings 1992 Springer-Verlag Berlin Heidelberg

情感

The Sympathoadrenal Progenitor of the Neural Crest: Basic Biology and Therapeutic Potential,rs into chromaffin cells, whereas fibroblast growth factor (FGF) and nerve growth factor (NGF) promote their development into sympathetic neurons. FGF and NGF appear to act sequentially; the former factor promotes neurite outgrowth and proliferation while the latter factor supports the survival of p

PATHY

Immortal Mammalian Neuronal Stem Cells Differentiate after Implantation into the Developing Brain,ll types in the Drosophila retina (Van Vactor et al. 1991; Simon et al. 1991). Transplants of neuroepithelial cells also show that local extracellular signals also regulate the fate of the multipotential neuronal precursors in mammals. A crucial signalling step that commits the multipotential precur

NUL

Establishment of Clonal Cell Lines for the Study of Neural Function and Dysfunction,te the degenerative process. In fact, it is quite possible that the grafted cells themselves could succumb to the basic disease process. In neurological disorders such as Alzheimer’s disease (AD; Fig. 1a), a variety of neural pathways are selectively vulnerable and not all of the neurotransmitter de

JOT

絕種

Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors, short- and long-term expression of foreign genes on neurons in the peripheral and central nervous systems. Examples will be given here for gene delivery to the adult rat nervous system using vectors which lack viral thymidine kinase activity and cannot replicate in neurons, focusing on the use of t

zonules

Gene Transfer of a Murine Dystrophin Minigene Construct,, a modified vector based on the muscle creatine kinase promoter with the El and E2 enhancers was developed to drive the dystrophin cDNA. Microinjection of this construct into a mouse ovum resulted in a transgenic mouse with a single copy integration of the dystrophin cDNA. Dystrophin expression in

轉(zhuǎn)向

Gene Therapy in Animal Models of Neurological Disorders,al tissue. In the grafted striatum, both fibroblast and endocrine cells restored normal levels of extracellular fluid DA. Release of dopamine from fibroblasts was notably unaffected by high concentrations of potassium, in agreement with the . properties of the grafted cells. The intrastriatal grafts

atopic-rhinitis

Neurotrophins and their Receptors,els of NGF, BDNF and NT-3 mRNAs are found within the hippocampus, where they are expressed in a unique set of neurons. Both BDNF and NT-3 mRNAs are transiently expressed in some brain regions during postnatal brain development, suggesting that trophic interactions during brain development are a dyna

Brochure

Viral Hepatitis in the Compromised Host,Somatic cell gene therapy for the correction of many human genetic diseases is now technically possible. We review several methods and cell types that can be used successfully in gene transfer studies in animals, and discuss their potential promise and limitations in the treatment of human genetic diseases.

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