Titlebook: Epigenetics: Development and Disease; Tapas K. Kundu Book 2013 Springer Science+Business Media Dordrecht 2013 Cancer and diabetes.Chromati

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https://doi.org/10.1007/978-3-662-39501-1ity, Pol II is subject to a host of factors that regulate the multistep transcription process. Indeed, the hallmark of the transcription cycle is the dynamic association of Pol II with initiation, elongation and other factors. In addition, Pol II transcription is regulated by a series of cofactors (

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https://doi.org/10.1007/978-3-662-39564-6tones, such as acetylation, phosphorylation and methylation have been linked to Pol III transcriptional activity. In addition to being regulated by modifications of DNA and histones, Pol III genes and its transcription factors have been implicated in the organization of nuclear chromatin in several

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https://doi.org/10.1007/978-3-662-39565-3e, transcriptional regulation still cannot be explained solely by an individual’s DNA sequence. Complex coordination and communication between a plethora of well-conserved chromatin modifying factors are essential for all organisms. Regulation of gene expression depends on histone post translational

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