Titlebook: Epigenetics: Development and Disease; Tapas K. Kundu Book 2013 Springer Science+Business Media Dordrecht 2013 Cancer and diabetes.Chromati

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The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Contextity, Pol II is subject to a host of factors that regulate the multistep transcription process. Indeed, the hallmark of the transcription cycle is the dynamic association of Pol II with initiation, elongation and other factors. In addition, Pol II transcription is regulated by a series of cofactors (

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The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humanse, transcriptional regulation still cannot be explained solely by an individual’s DNA sequence. Complex coordination and communication between a plethora of well-conserved chromatin modifying factors are essential for all organisms. Regulation of gene expression depends on histone post translational

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Histone Variants and Transcription Regulationed during S phase of the cell cycle, there exist variants of canonical histones that are expressed throughout the cell cycle. These histone variants are often deposited at defined regions of the genome and they play important roles in a variety of cellular processes, such as transcription regulation

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Chromatin Structure and Organization: The Relation with Gene Expression During Development and Diseaen chromatin domains and ultimately chromosome territories. These successive folding levels rely on the formation of chromatin loops ranging from few kb to some Mb. In addition to a packaging and structural role, the high-order organization of genomes functionally impacts on gene expression program.

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Metabolic Aspects of Epigenome: Coupling of ,-Adenosylmethionine Synthesis and Gene Regulation on Chepression by MafK and its partner Bach1. Because the catalytic activity of MATIIα is required for the MafK target gene repression, MATIIα is suggested to provide SAM locally on chromatin where it is recruited. One of the unexpected features of MATII is that MATIIα interacts with many chromatin-relat