Titlebook: Epigenetics and Disease; Pharmaceutical Oppor Susan M. Gasser,En Li Book 2011 Springer Basel AG 2011 DNA methylation.cancer.neuronal disord

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DNA Methylation and Cancer,. Aberrant DNA methylation patterns are acquired during carcinogenic transformation; such events are often accompanied by alterations in chromatin structure at gene regulatory regions. The expression pattern of any given gene is achieved by interacting epigenetic mechanisms. First, the insertion of

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DNA Repair and the Control of DNA Methylation,provided by epigenetic mechanisms that facilitate a selective readout of the genome. Operating at the level of chromatin, they establish defined gene expression programs during cell differentiation. Among the epigenetic modifications in mammalian chromatin, the 5′-methylation of cytosine in CpG dinu

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Histone Modifications in Cancer Biology and Prognosis,t various DNA-based processes, such as gene regulation. Histones are proteins around which the DNA wraps itself to form chromatin – the physiologically relevant form of the human genome. Histones are modified extensively by posttranslational modifications that alter chromatin structure and serve to

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Dynamics of Histone Lysine Methylation: Structures of Methyl Writers and Erasers,esses acting on DNA. ATP-dependent chromatin remodeling machines and histone-modifying complexes can overcome this barrier (or strengthen it in silencing processes). Both components of chromatin (DNA and histones) are subject to postsynthetic covalent modifications, including methylation of lysines

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Epigenetic Mechanisms of Mental Retardation,me incorporates a highly diverse group of mental disorders characterized by the combination of cognitive impairment and defective adaptive behavior. The genetic basis of the disease is strongly supported by identification of the genetic lesions associated with impaired cognition, learning, and socia

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