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Titlebook: Epigenetics and Disease; Pharmaceutical Oppor Susan M. Gasser,En Li Book 2011 Springer Basel AG 2011 DNA methylation.cancer.neuronal disord

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發(fā)表于 2025-3-21 18:08:47 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Epigenetics and Disease
副標(biāo)題Pharmaceutical Oppor
編輯Susan M. Gasser,En Li
視頻videohttp://file.papertrans.cn/314/313235/313235.mp4
概述Discusses new approaches to pharmaceutical intervention.Includes new findings from stem cell research.With numerous illustrations.Includes supplementary material:
叢書名稱Progress in Drug Research
圖書封面Titlebook: Epigenetics and Disease; Pharmaceutical Oppor Susan M. Gasser,En Li Book 2011 Springer Basel AG 2011 DNA methylation.cancer.neuronal disord
描述Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs.Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.
出版日期Book 2011
關(guān)鍵詞DNA methylation; cancer; neuronal disorders; stem cells; therapy
版次1
doihttps://doi.org/10.1007/978-3-7643-8989-5
isbn_softcover978-3-0348-0305-2
isbn_ebook978-3-7643-8989-5Series ISSN 0071-786X Series E-ISSN 2297-4555
issn_series 0071-786X
copyrightSpringer Basel AG 2011
The information of publication is updating

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發(fā)表于 2025-3-21 22:17:31 | 只看該作者
America, Pakistan, and the India Factorysine demethylases (erasers). Importantly, epigenetic modifications impact chromatin structure directly or can be read by effector regulatory modules. Here, we summarize current knowledge on structural and functional properties of various histone lysine methyltransfereases and demethylases, with emphasis on their importance as druggable targets.
板凳
發(fā)表于 2025-3-22 03:53:02 | 只看該作者
https://doi.org/10.1007/978-94-6209-878-7ed in important human diseases, including cancer and hepatitis C. We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases.
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發(fā)表于 2025-3-22 07:44:13 | 只看該作者
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The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential,ed in important human diseases, including cancer and hepatitis C. We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases.
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發(fā)表于 2025-3-22 19:40:40 | 只看該作者
Small Molecules in Cellular Reprogramming and Differentiation,tions, but also such small molecules could be further developed as conventional therapeutics to target patient’s own cells residing in different tissues/organs for treating degenerative diseases, injuries, and cancer. Here, we will review recent studies of small molecules in controlling cell fate.
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發(fā)表于 2025-3-23 01:48:40 | 只看該作者
https://doi.org/10.1057/9781137432841 of epigenetic regulators, highlighting a potentially new avenue for therapeutic intervention. In this review, we discuss recent studies on epigenetic regulation in MR and explore the concept of epigenetic therapy for MR.
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發(fā)表于 2025-3-23 05:58:32 | 只看該作者
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