Titlebook: Engineering Translational Models of Lung Homeostasis and Disease; Chelsea M. Magin Book 2023 The Editor(s) (if applicable) and The Author(

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An Introduction to Engineering and Modeling the Lung,uencing, induced pluripotent stem cell (iPSC) reprogramming, and 3D cell and tissue culture. Despite rigorous research and tireless efforts, chronic pulmonary diseases remain the third leading cause of death globally, with transplantation being the only option for treating end-stage disease. This ch

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Simple Models of Lung Developmentments for lung diseases. A wide variety of rodent and human models are available that recapitulate one or more stages of lung development. This chapter describes the existing ‘simple’ in vitro, in silico and ex vivo models of lung development. We define which stage(s) of development each model recap

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Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesipment, multipotent mesenchymal and epithelial progenitors drive the diversification of fates that results to the plethora of cell types that compose the airways and alveolar space of the adult lungs. Use of mouse genetic models, including lineage tracing and loss-of-function studies, has elucidated

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Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways physiological role of the large airways is to move a large amount of air to and from the gas exchange surfaces of the alveoli. This air becomes divided along the respiratory tree as it moves from the large airways to smaller airways, bronchioles, and alveoli. The large airways are incredibly import

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Engineering and Modeling the Lung Mesenchymelized cells in the lung mesenchyme produce the extracellular matrix (ECM) and growth factors required for lung structure. Historically, characterizing the mesenchymal cell subtypes was challenging due to their ambiguous morphology, overlapping expression of protein markers, and limited cell-surface

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