Titlebook: Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery; Electrically Mediate Mark J. Jaroszeski,Richard Heller,Richard Gilb

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Mechanistic Studies of Skin Electroporation Using Biophysical Methodsion was first observed almost three decades ago. Determining the mechanism by which such pulses permeabilize the complex, multilamellar bilayer structures in skin poses an even greater challenge. To address this issue, a range of methods have been employed to perform biophysical characterization for

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Treatment of Multiple Spontaneous Breast Tumors in Mice Using Electrochemotherapyrmeabilization. Electrochemotherapy has been proven to be highly efficient as a local antitumor treatment on transplanted tumors (.). Indeed, electrochemotherapy resulted in high rates of tumor responses and even cures in preclinical trials on different experimental murine tumors (.). Treatment effi

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Mechanistic Studies of Skin Electroporation Using Biophysical Methodsures in skin poses an even greater challenge. To address this issue, a range of methods have been employed to perform biophysical characterization for skin electroporation studies. In this chapter, we provide an overview of these methods and highlight representative findings which biophysical characterization has yielded.