Titlebook: Electrical Diseases of the Heart; Genetics, Mechanisms Ihor Gussak (Deputy Therapeutic Area Head, Profess Book 20081st edition Springer-Ver

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Neural Regulation of the Heart in Health and Diseasework of intrinsic cardiac nerves, and autonomic reflexes, all of which interact with a cardiac substrate altered by advancing age and disease. In patients with ischemic heart disease, which is the major factor underlying risk for sudden cardiac death (SCD),. neural influences can predispose to arrhy

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Mechanisms of Action of Antiarrhythmic Drugs clinics for a long time. Arrhythmias refer to changes from the normal sequence of electrical impulses and conduction, causing abnormal heart rhythms. They can be classified into two categories: bradyarrhythmias and tachyarrhythmias. Both can make the heart pump less effectively and, more seriously,

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The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribuum (Figure 8-1).. Reperfusion of the ischemic heart may further exacerbate an ischemia-induced loss of ionic homeostasis. Ischemia and ischemic metabolites can increase the influx of sodium into myocytes..–. Concurrent reduction of sodium efflux during ischemia, as a consequence of reductions of cel

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Sodium Ion Channelopathies rapid impulse conduction through cardiac tissue. Therefore, Na. channel function plays a major role in initiation, propagation, and maintenance of the normal cardiac rhythm. Mutations in SCN5A, the gene encoding for the α-subunit of the cardiac Na. channel, the so-called “inherited sodium channelop

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L-type Calcium Channel Diseaseciated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of Timothy syndrome (TS). TS is a variant of the long QT syndrome (also LQT8) and it is a rare and

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Channelopathies of Cardiac Inwardly Rectifying Potassium Channelsstanding the molecular basis of an ion channel disease has provided new opportunities for screening, early diagnosis, and therapy of these commonly life-threatening conditions. ., . A case in point is the identification of molecular genetic defects in inwardly rectifying potassium (Kir, .) channels.

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