Titlebook: Drugs of Abuse; Neurological Reviews John Q. Wang Book 2003 Humana Press 2003

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Systematic Screening of Gene Expression Using a cDNA Macroarraynd addiction. It is clear that the mechanisms will involve psychosocial, behavioral, neuroanatomical, and molecular biological components. This last facet, the molecular component, is the subject of the present discussion and the motivation for the use of DNA arrays. Although the contributions of so

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Neuropharmacology and Neurotoxicity of 3,4-Methylenedioxymethamphetamines in laboratory animals and humans indicate that repeated exposure to MDMA elicits long-term changes in neurochemistry and behavior that are viewed as resulting from a selective neurotoxicity of 5-hydroxytryptamine (5-HT)-containing axon terminals.

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Analysis of Gene Expression in Striatal Tissue by Multiprobe RNase Protection Assayhain reaction (RT-PCR), and ribonuclease (RNase) protection assay. Each method has its own strengths and limitations, and these factors must be evaluated carefully to determine the method most appropriate for the given problem.

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Analysis of mRNA Expression in Striatal Tissue by Differential Display Polymerase Chain Reactionessed mRNA population. By performing parallel sets of reactions for each experimental condition and displaying the resulting fingerprints side by side, bands that differ between conditions can be noted and the corresponding mRNA identified.

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