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Titlebook: Drug Studies in the Elderly; Methodological Conce Neal R. Cutler (Director),Prem K. Narang (Supervis Book 1986 Plenum Publishing Corporatio

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書(shū)目名稱(chēng)Drug Studies in the Elderly
副標(biāo)題Methodological Conce
編輯Neal R. Cutler (Director),Prem K. Narang (Supervis
視頻videohttp://file.papertrans.cn/284/283128/283128.mp4
圖書(shū)封面Titlebook: Drug Studies in the Elderly; Methodological Conce Neal R. Cutler (Director),Prem K. Narang (Supervis Book 1986 Plenum Publishing Corporatio
描述Clinical trials are the most definitive tool for evaluation of the applica- bility of clinical investigations. The main objective of clinical investiga- tions is to assess the potential value of a therapeutic entity in the treat- ment or prophylaxis of a disease or a condition. It is also deemed necessary at this stage to obtain information regarding the undesirable side effects, associated risks, and their interrelationship with clinical assessments. Most of these clinical investigations conform, in some form or fashion, to the guidelines adopted by the Food and Drug Administration (FDA) for a given class of compounds. Clinical investigations in the past have not included specific studies in special or subpopulations, e.g., the elderly. Because of an ever-increasing elderly population, newer policies for clinical investigations are now being debated with the recognition of enhanced drug sensitivity in this special population. This key research activity can lead not only to improved health care in the elderly but also to control of its costs.
出版日期Book 1986
關(guān)鍵詞Alzheimer; Assessment; Thymus; Transplantation; age; dementia; dopamine
版次1
doihttps://doi.org/10.1007/978-1-4684-1253-6
isbn_softcover978-1-4684-1255-0
isbn_ebook978-1-4684-1253-6
copyrightPlenum Publishing Corporation 1986
The information of publication is updating

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G,ictated by demographic changes. As can be seen from Fig. 1, based on current projections, the present U.S. population of older people (those 65 years of age and over) will have more than doubled by the year 2030.. It is expected that over 50 million people will belong to this group and will constitu
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H, It may be reasonable to relate the increasing incidence of infection or cancer to immune senescence. The precise contribution of changing immune competence to other diseases of aging such as Alzheimer’s disease, atherosclerosis, and diabetes must be considered speculative. However, extensive basic
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I,ears and is followed by a gradual, often linear decline.. Many physiological and biochemical changes occur with “normal” aging. In addition, concomitant pathological conditions, lifelong habits, and environmental exposure also contribute to the biological changes in the elderly. As a result, there a
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L,have been correlated with therapeutic effects. It is thus important to understand the influence of various factors such as age, disease states, and concurrent therapy on the drug’s kinetics, as these factors often alter drug pharmacokinetics (and therefore therapeutic efficacy) and are present in a
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