Titlebook: Discovering and Developing Molecules with Optimal Drug-Like Properties; Allen C Templeton,Stephen R. Byrn,Thomas E. Prisin Book 2015 Ameri

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Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processesneed to execute in a parallel fashion. These realities in turn can place severe restrictions on the options available to the development and implementation of drug delivery strategies. While one would expect the contrary, these realities do not preclude the use of development-stage formulation techn

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Diagnosing Biopharmaceutical Limitationsands adequate exposure throughout the dosing interval and none of the compounds tested approaches the targeted exposure. Studying compounds to determine why exposure is poor may assist the structure–activity relationship (SAR) process, even if the compounds are not suitable for further development.

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Practical Considerations for Spray Dried Formulation and Process Developmentug to a high energy polymer stabilized amorphous state. Spray drying is a mature process with demonstrated production capability from lab to commercial scale for manufacturing amorphous solid dispersions. However, the impact of the drying process on the performance, manufacture, and stability of the