Titlebook: Development of Antibody-Based Therapeutics; Translational Consid Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Kla Book 20121st edition Sp

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Considerations in Manufacturing Process Development for Antibody-Based Therapeutics,ntinues to grow, development of robust manufacturing processes has been a significant focus within the pharmaceutical industry. This chapter describes the work-processes, challenges, and opportunities for platform production of antibodies with a focus on production for use in human clinical trials a

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Strategies for Development of Next Generation Antibody-Based Therapeutics, growth of the biologics market. As next generation modalities confront their first-generation rivals, it is critical that next generation products present a clear differentiating advantage over the existing competition and hence offer the potential to displace their first-generation rivals based on

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Immune Complex Therapies for Treatment of Immune Thrombocytopenia,st several years, several published reports have suggested that gamma globulin immune complexes may inhibit pathways of platelet destruction in ITP, attenuating thrombocytopenia in human patients and in animal models of ITP. This chapter reviews the literature associated with the use of immune compl

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Application of Bioinformatics Principles for Target Evaluation,

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Im Bereiche der rhythmischen Schwankungen,, and linking PK/PD relationships to clinical outcomes. To improve prospective model predictions of drug efficacy and safety, new approaches will be needed to link antibody disposition with robust systems pharmacology models of drug and disease mechanisms.

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Application of Pharmacokinetic/Pharmacodynamic Modeling in the Development of Antibody-Based Therap, and linking PK/PD relationships to clinical outcomes. To improve prospective model predictions of drug efficacy and safety, new approaches will be needed to link antibody disposition with robust systems pharmacology models of drug and disease mechanisms.