Titlebook: Development of Antibody-Based Therapeutics; Translational Consid Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Kla Book 20121st edition Sp

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https://doi.org/10.1007/978-1-4419-5955-3Antibody; Antibody-Based; Bornstein; Considerations; Development; Klakamp; Tabrizi; Therepeutic; Translation

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978-1-4899-9113-3Springer Science+Business Media, LLC, part of Springer Nature 2012

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Grundgesetz und Interessenverb?ndentinues to grow, development of robust manufacturing processes has been a significant focus within the pharmaceutical industry. This chapter describes the work-processes, challenges, and opportunities for platform production of antibodies with a focus on production for use in human clinical trials and marketing applications.

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Translational Strategies for Development of Antibody-Based Therapeutics: An Overview,th a diverse array of soluble or cell-associated target antigens. Much like traditional small molecule drugs, a major challenge during the development of antibody-based therapeutics is maintaining an effective information flow and translation of accumulated knowledge throughout the various developme

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Technologies for the Generation of Human Antibodies,States. With the passing of time, new technological developments together with competition for finite markets have continually raised the bar for the specifications of newly introduced antibodies. Our intent in this review is to provide a historical perspective on the technologies that have generate

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Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutifects of antibody-based drugs. Advances in protein engineering technologies afforded investigators the ability to overcome problems associated with introducing foreign antibodies into humans. These efforts included antibody chimerization, humanization, and the more recent development of human antibo