Titlebook: Deoxynucleoside Analogs in Cancer Therapy; Godefridus J. Peters (Professor of Medical Oncolog Book 2006 Humana Press 2006 HIV.cancer.cance

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Nucleoside Transport Into Cells,NT; SLC29 gene family) nucleoside transporters, which differ in their substrate selectivity and their energy requirements. Both nucleoside transporter families have also been involved in the transmembrane transport of nucleoside-derived compounds, many of them currently used in antiviral and antitum

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The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation,nly enzyme that can supply cells with all four precursors of DNA; is capable of 5′-phosphorylation of the natural substrates deoxycytidine (dCyt), deoxyadenosine, and deoxyguanosine; and can be interconverted into thymine nucleotides. The deoxycytidine triphosphate (dCTP), in addition to DNA, can be

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Clofarabine,the drug in acute leukemias is favorable relative to fludarabine or cladribine and may have prognostic value for its clinical activity. The toxicity profile of this agent is different from other nucleoside analogs in that it clearly has clinical activity when used as a single agent against adult acu

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,-Nucleosides as Chemotherapeutic Agents,des and nucleoside analogs are available. Among nucleoside analogs, nonnatural L-enantiomers have been particularly interesting. The most notable example is lamivudine, which has been playing an important role in the treatment of human immunodeficiency virus and hepatitis B virus infections. The rea

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,9-β-,-Arabinofuranosylguanine,1995 before a prodrug of ara-G, nelarabine, entered clinical trials. Ara-G is a deoxyguanosine analog that needs to be phosphorylated inside the cell for pharmacological activity. In the first and rate-limiting phosphorylation step, ara-G is a substrate of both the mitochondrial deoxyguanosine kinas