Titlebook: DNA and Histone Methylation as Cancer Targets; Atsushi Kaneda,Yu-ichi Tsukada Book 2017 Springer International Publishing AG 2017 Demethyl

Tempor

evince

Shida Li,Wenjie Zhou,Yunfang Wu and DNA repair/housekeeping genes. One of the major clinical needs is the discovery and clinical validation of new molecular biomarkers using non-or minimally invasive procedures to assist early diagnosis, prognosis and prediction of response to treatment. Histone methylation has profound effects o

Ceramic

https://doi.org/10.1007/978-3-319-59786-7Demethylation; DNA; Histone; Hypermethylation; Methylation

生來(lái)

978-3-319-86700-7Springer International Publishing AG 2017

僵硬

DNA and Histone Methylation as Cancer Targets978-3-319-59786-7Series ISSN 2196-9906 Series E-ISSN 2196-9914

Conspiracy

Xiaobo Wu,Wanling Ding,Yongjiang Shil processes through divergent transcription activities. Recently, aberrant histone modifications have been shown to contribute significantly towards many diseases, notably cancer. Here, we summarize the known drivers leading to misregulation of DNA and histone methylation in cancer, and current therapeutic options to counter these aberrations.

消瘦

modest

Misregulation of Histone Methylation Regulators in Cancerl processes through divergent transcription activities. Recently, aberrant histone modifications have been shown to contribute significantly towards many diseases, notably cancer. Here, we summarize the known drivers leading to misregulation of DNA and histone methylation in cancer, and current therapeutic options to counter these aberrations.

committed

清楚說(shuō)話

The Molecular Basis of Histone Methylationf binding proteins at multiple molecular layers. Given?that the disruption of histone methylation and recognition has been associated with altered gene function in various diseases and human malignancy, understanding the regulation of histone methylation and recognition will also provide molecular b