Titlebook: DNA and Histone Methylation as Cancer Targets; Atsushi Kaneda,Yu-ichi Tsukada Book 2017 Springer International Publishing AG 2017 Demethyl

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The Molecular Basis of DNA Methylationand is crucial for development, especially in higher eukaryotes. Three DNA (cytosine-5)-methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been identified. Dnmt3a and Dnmt3b are mainly responsible for establishing DNA methylation patterns in the genome. Factors interacting with Dnmt3a or Dnmt3b, hi

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The Molecular Basis of DNA Demethylationng DNA methylation have been well characterized, those involved in demethylation have remained elusive until recently. Mounting evidence now suggests that the TET proteins, a family of AlkB-like Fe(II)/α-ketoglutarate-dependent dioxygenases, initiate active DNA demethylation by oxidizing 5-methylcyt

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Misregulation of Histone Methylation Regulators in Cancerl processes through divergent transcription activities. Recently, aberrant histone modifications have been shown to contribute significantly towards many diseases, notably cancer. Here, we summarize the known drivers leading to misregulation of DNA and histone methylation in cancer, and current ther

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DNA Methylation and Dysregulation of miRNA in Cancerthe expression of protein coding/noncoding RNAs by repressing translation or cleaving RNA transcripts in a sequence-depending manner. The unique characteristic function of miRNAs is to regulate RNA transcripts in human cells. Therefore, dysregulated expression of miRNAs can disrupt tightly regulated