Titlebook: DNA Modifications; Methods and Protocol Alexey Ruzov,Martin Gering Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusi

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Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tanbolic processes. 8-oxoguanine, one of the oxidatively modified DNA bases is a typical biomarker of oxidative stress. A noncanonical base, uracil, may also be present in small quantities in DNA. Ten-eleven translocation (TET) proteins are involved in oxidation of 5-methylcytosine to 5-hydroxymethylcy

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Preparation of Internal Standards for 2D-UPLC-MS/MS Quantification of Noncanonical DNA Basesnternal standards. Only some of them are commercially available. Here we present a method allowing for the synthesis of [.C.,.N.]-5-methyl-2′-deoxycytidine from [.C.,.N.]-2′-deoxythymidine. We also describe an approach for the oxidation of [.C.,.N.]-5-methyl-2′-deoxycytidine and [.C.,.N.]-2′-deoxyth