Titlebook: DNA Methylation and Cancer Therapy; Moshe Szyf Book 2005 Springer-Verlag US 2005 DNA.Expression.Microarray.Purine.enzymes.gene expression.

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https://doi.org/10.1007/978-3-642-24996-9 regional hypermethylation in cancer is required for the proper design of therapeutic strategies targeting the DNA methylation machinery. This chapter discusses different models explaining this paradox. Global hypomethylation is proposed to be associated with activation by demethylation of metastasi

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https://doi.org/10.1007/978-3-476-05319-0ethylation are reviewed. These include studies on the molecular, cellular and animal pharmacology of 5AZA. These preclinical studies indicated that 5AZA has enormous potential in cancer therapy. This potential is supported by reports in the literature indicate that 5AZA can reactivate many different

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https://doi.org/10.1007/978-3-476-05319-0RNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an antican

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https://doi.org/10.1007/978-3-476-05319-0RNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an anticancer gene therapy.

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Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense,RNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an anticancer gene therapy.

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Moshe SzyfDNA Methylation and Cancer Theraphy focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials..The chapters are

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978-1-4419-3416-1Springer-Verlag US 2005