Titlebook: Cancer Cell Dormancy; Methods and Protocol Marco Montagner Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Advances in Service and Industrial Roboticssome survive and enter a state of dormancy and chemoresistance due to their close interaction with cells in the bone marrow hematopoietic niche. Over many years, some of the cells reawaken and result in metastatic disease that cannot be cured. Analyzing the cellular and molecular interactions betwee

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Advances in Service and Industrial Roboticspitulates the complex tumor microenvironment. The chicken embryo chorioallantoic membrane (CAM) is an in vivo system suitable for the implantation of xenograft tumor models. It allows the study of different aspects of the metastatic process, including the dormancy-awakening transition. The main adva

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Advances in Service and Industrial Roboticst the need for exogenous supplementation of hormones. The naturally low 17-β-estradiol levels in host mice recapitulate levels seen in post-menopausal women. By introducing breast cancer cells directly into their “natural” microenvironment of the milk ducts, these cells maintain hormone receptor sta

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Kinematics of the “Ai-Gerim” Robot Armsting cure (Aguirre-Ghiso, Nat Rev Cancer 7:834–846, 2007; Klein, Nat Rev Cancer 20(11):681–694, 2020; Lyden et al. Cancer Cell 40:787–791, 2022). Despite its clinical significance, the study of what drives DTCs in and out of dormancy while they linger in distant sites has been challenged by the lac

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