Titlebook: Cryo-Electron Tomography; Structural Biology i Friedrich F?rster,Ariane Briegel Book 2024 The Editor(s) (if applicable) and The Author(s),

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Targeting, Localisation and Identification in Cryo-ET,sequence of this direct imaging is that every molecule in the sample contributes to the resulting tomogram, and for complex specimens such as cells or viruses, it can be challenging to identify a specific feature of interest. This chapter discusses two approaches to help guide collection and interpr