Titlebook: Computational Methods for SNPs and Haplotype Inference; DIMACS/RECOMB Satell Sorin Istrail,Michael Waterman,Andrew Clark Conference proceed

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Computational Methods for SNPs and Haplotype Inference978-3-540-24719-7Series ISSN 0302-9743 Series E-ISSN 1611-3349

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Hiromi Watanabe,Girish Beedesseegle nucleotide polymorphisms (SNPs) are the most common form of genomic variation. Haplotypes have been suggested as one means for reducing the complexity of studying SNPs. In this paper we review some of the computational approaches that have been taking for determining haplotypes and suggest new approaches.

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Lecture Notes in Computer Sciencehttp://image.papertrans.cn/c/image/232743.jpg

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Bayesian Methods for Statistical Reconstruction of Haplotypesbution, and the computational methods used to approximate posterior distributions. We describe recent improvements to the software PHASE, including handling missing data and improved computational methods, and compare its behaviour to some other published methods.