Titlebook: Clinical Relevance of Genetic Factors in Pulmonary Diseases; Takeshi Kaneko Book 2018 Springer Nature Singapore Pte Ltd. 2018 Smoking.Bron

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Andrew C. Chang,Deborah Brawer Silva last 50?years. Malignant mesothelioma is characterized by a long latency period of 40?years between initial exposure to asbestos and tumor development, indicating that multiple somatic genetic alterations contribute to its carcinogenesis. Molecular genetic studies have identified multiple chromosom

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Approaches to Understanding the Genetic Basis of Complex Diseases: Overview—What Is the Rationale fove revealed the genetic components of common diseases. Genetic mapping is an unbiased method to comprehensively identify genes and biological pathways involved in diseases or traits. Genome-wide association studies (GWASs) have convincingly identified disease-associated loci. Most of the associated

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COPD: Hereditary (A1-AT) and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesi This is because approximately 15% of the smoking population eventually suffer from this disease, while the others sustain normal lungs despite their smoking habit. A well-known causal gene of COPD is the serine protease inhibitor A1 (SERPINA1) gene, which causes hereditary severe α1-antitrypsin (A1

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Cystic Fibrosis, Primary Ciliary Dyskinesia, and Diffuse Panbronchiolitis: Hereditary and Non-heredining genetic disorder in Caucasians, caused by mutations in a single gene on the long arm of chromosome 7 that encodes the cystic fibrosis transmembrane conductance regulator (CFTR). The predominant CFTR mutation is Phe508del, yet more than 2000 variants in this gene have been identified, which can