Titlebook: Chemokine Receptors in Cancer; Amy M. Fulton Book 2009 Humana Press 2009 angiogenesis.cytokines.metastasis.prostate cancer.tumor

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G. Barucchi,G. Ponzano,T. Regge5 and CCR5 in patients, their associations with disease course and experiments that were performed in animal model systems in order to decipher the roles of the CCL5/CCR5 axis in tumor growth and metastasis. In addition, we describe possible mechanisms mediating the activity of this pair in specific

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Book 2009. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a dive

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CXCR4 and Cancer,sses including organogenesis, hematopoiesis, and immunity. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including cancer and WHIM syndrome. Expression of CXCR4 in cancer metastasis appears to be due to dysregulation of the receptor leading to enhanced signaling. CXCR4 w

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Chemokine Receptors Involved in Colon Cancer Progression, and Lymph Node Metastasis,t, inactivation of TGF-β family signaling within colon cancer epithelium increases chemokine CCL9, and promotes recruitment of the MMP-expressing stromal cells that carry CCR1, the cognate receptor for CCL9. Consistently, lack of CCR1 prevents the accumulation of MMP-expressing myeloid cells at the

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The CCL5/CCR5 Axis in Cancer,nvolvement also in malignant diseases. This chapter focuses on CCL5 (RANTES) and its CCR5 receptor in cancer, describing their expression patterns, activities, and roles in several malignancies. Thus far, CCL5 and/or CCR5 have been detected in many hematological malignancies and in a large number of