Titlebook: Chemical Carcinogenesis; Models and Mechanism Francesco Feo,Paolo Pani,Renato Garcea Book 1988 Springer Science+Business Media New York 198

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Enzymatic Detoxication of Tumorigenic Bay-Region Diol-Epoxides of Polycyclic Aromatic Hydrocarbons bent binding of (+)-anti-BPDE to the exocyclic nitrogen of deoxyguanosine in DNA of target tissues is closely correlated with tumor formation.. Thus, it is likely that enzymatic and non-enzymatic processes that prevent intracellular accumulation of PAH diol-epoxides will counteract DNA-damage and res

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Liver DNA Damage by Chemical Carcinogens: Role of Thyroid Hormoneselopment of liver tumors. These findings were confirmed by Goodall. who demonstrated that in thyroidectomized animals the treatment with thyroid digest performed after aminofluorene administration does not restore the suscciptibility to the carcinogen. Moreover, thyroid hormones have been demonstrat

microscopic

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cally recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.978-1-4757-9642-1978-1-4757-9640-7

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VB 2008 Programming Constructs, Part Iytochromes P-450 have been shown to play a major role in this process (reviewed in ref. 8). In this paper, the catalytic activity of specific cytochrome P-450 isozymes for the activation of these carcinogens will be discussed in relation to species and individual differences in cancer susceptibility

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VB 2008 Programming Constructs, Part Iransformation of C3H10T1/2 cells than is the simple bay-region diol-epoxide of chrysene.. Furthermore, after application of chrysene to mouse skin, a target organ for carcinogenicity, this triol-epoxide forms a major type of DNA-adduct.. The higher chemical reactivity and biological activity of 9-hy

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Designing Encapsulated Class Typesent binding of (+)-anti-BPDE to the exocyclic nitrogen of deoxyguanosine in DNA of target tissues is closely correlated with tumor formation.. Thus, it is likely that enzymatic and non-enzymatic processes that prevent intracellular accumulation of PAH diol-epoxides will counteract DNA-damage and res

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