Titlebook: Central Nervous System Leukemia; Prevention and Treat Renato Mastrangelo,David G. Poplack,Riccardo Ricca Book 1983 Martinus Nijhoff Publish

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Treatment of Overt CNS Leukaemia,roach of intrathecal Methotrexate (IT MTX) to clear the CSF of blast cells followed by craniospinal radiotherapy. In those randomized to have cranial only, rather than craniospinal, radiotherapy there was no comparable benefit; 8 out of 8 developing further CNS relapse. These results were obtained i

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Treatment of Meningeal Leukemia: Investigation of New Approaches with Conventional Agents,ority of cases, remission durations are usually short and most patients suffer subsequent relapse. A major barrier to the identification of successful chemotherapeutic approaches to the treatment of overt meningeal leukemia is the fact that only a few antineoplastic agents are appropriate for intrat

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https://doi.org/10.1007/978-3-642-74938-4elsewhere in this book, have indicated the potential adverse effects of the combination of cranial irradiation and intrathecal methotrexate. Therefore we have tried to avoid prophylactic cranial irradiation in our treatment protocol.

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https://doi.org/10.1007/978-3-642-74697-0Two principal methods have been employed for irradiating the brain, spinal cord, or both to prevent meningeal leukemia in children. The most common method is external beam irradiation, and the second is the instillation of radiocolloids in the subarachnoid space.

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