Titlebook: Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres; John M. G. Davis,Marie-Claude Jaurand Conference proceedings 199

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Cytotoxicity and cell stimulating activity of ultrafine titanium dioxideels normally existing at the working places (Ferin et al. 1985, Richards et al 1985). However, exposure to very high concentrations of Ti0. dust has caused mild fibrosis and malignant tumors in experimental animals (Trochimowicz et al. 1988).

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DNA and Chromosome Damage Produced by Some Minerals and Man Made Particles on Rat Pleural Mesothelcts of potential carcinogens at the DNA and chromosome level. To use these assays as predictive or mechanistic models, one important point is to determine whether differences exist between cell responses to carcinogenic/non carcinogenic particles and why?

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Stochastic Processes and Markov Chains,er in the development of this disease (Mossman et al. 1990). However, the development of malignant mesothelioma in the pleura is not associated with cigarette smoking. The generally accepted view is that amphibole asbestos acts as a complete carcinogen in the development of mesothelioma (Mossman et al.1990).

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1010-8793 n Vivo Dust-Related Pathological Processes. Correlations Between in Vitro and in Vivo Data - Physico-Chemical Properties of Minerals in Relation to Their Biological Effects.978-3-642-79043-0978-3-642-79041-6Series ISSN 1010-8793

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https://doi.org/10.1007/978-3-642-05404-4icles became available. One of the aims of the present study was to reevaluate our previous data with really pure material. In addition, the hemolytic properties were tested and the interaction of C. with superoxide anion production was investigated.

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The Second Messenger System in Diseases Caused by Mineral Dustsnd mammalian cell systems, they are not classified as initiators for bronchogenic tumours although it is known that . fibres can enhance the effect of chemical or physical carcinogens causing cell transformation (Brown ., 1983; Hei ., 1985).

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Biological Effects of a New Type of Pure Carbon (Fullerenes) ,icles became available. One of the aims of the present study was to reevaluate our previous data with really pure material. In addition, the hemolytic properties were tested and the interaction of C. with superoxide anion production was investigated.

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Christian Melzer,Heinz von Seggernm to the underlying interstitial tissue (airway wall, alveolar interstitium), and in this location they can interact with interstitial macrophages to cause release of fibrogenic mediators, eventually leading to airway wall or interstitial fibrosis (Adamson et al 1989; Ferin et al 1992; Brody and Hill 1982).