Titlebook: Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres; John M. G. Davis,Marie-Claude Jaurand Conference proceedings 199

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Molecular Alterations in Murine Mesotheliomas Induced by Crocidolite Asbestosthelial cell injury is repaired by regeneration after 14–21 days. Weekly exposure to asbestos results in repeated episodes of injury, inflammation, and regeneration (Moalli .., (1987). We hypothesize that constitutive activation and/or deregulation of growth factor signaling pathways may contribute to the development of malignant mesothelioma.

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Conference proceedings 1994lowing areas: - Cellular and Metabolic Changes Caused by Mineral Dusts - Molecular Changes and DNA Alterations Produced by Mineral Dusts - In Vivo Dust-Related Pathological Processes. Correlations Between in Vitro and in Vivo Data - Physico-Chemical Properties of Minerals in Relation to Their Biological Effects.

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IS 2009 – PC Co-chairs’ Messageaspect ratio — See Hesterberg and Barrett, 1984; Stanton . 1981; reviewed in Harington, 1981). For this reason, a knowledge of how mineral fibers behave within interphase and dividing cells, and with what intracellular components they interact, becomes important in elucidating the mechanism(s) by which they cause cell injury.

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Involvement of the Oxidative Stress in the Toxicity of Iron-Containing Particles on Tracheal Epitheland particularly its surface reactivity are involved in particles toxicity. Indeed it has been shown that some mineral particles, including asbestos, can induce the production of activated oxygen species (AOS) in relation with the presence of divalent iron at the interface solid-liquid (Zalma et al, 1987a, Mossman and Marsh, 1989).

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