Titlebook: Cell Division Machinery and Disease; Monica Gotta,Patrick Meraldi Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusi

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Unbalanced Growth, Senescence and Aging,cellular and organismal aging phenotypes. The interplay between growth and division also underpins cellular senescence (i.e., inability to divide) and quiescence, when cells exit the cell cycle but still retain their ability to divide.

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Book 2017d the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented

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Metabolomics Analysis of OPLL Patientsficiently proliferate in the presence of extra centrosomes. Here, we review the adaptation mechanisms that allow cells to efficiently divide in the presence of extra centrosomes and how these could be exploited to develop selective cancer therapies.

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Metabolomics Analysis of OPLL Patientsmicrocephaly, and kinetochore defects contribute to chromosomal instability in certain cancers. This chapter gives an overview of the processes necessary for faithful chromosome segregation and how kinetochore malfunction causes various human pathologies.

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Polydipsia

Kinetochore Malfunction in Human Pathologies,microcephaly, and kinetochore defects contribute to chromosomal instability in certain cancers. This chapter gives an overview of the processes necessary for faithful chromosome segregation and how kinetochore malfunction causes various human pathologies.

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