Titlebook: Cell Division Machinery and Disease; Monica Gotta,Patrick Meraldi Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusi

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Huan Pang,Guangxun Zhang,Huaiguo Xueto the tissue defines the division plane. In turn, the orientation of cell division can regulate tissue morphology or the fate of daughter cells. While we have learned much about the mechanisms of mitotic spindle orientation, recent studies suggest that the proteins implicated can also play importan

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Cell Division Machinery and Disease978-3-319-57127-0Series ISSN 0065-2598 Series E-ISSN 2214-8019

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978-3-319-86083-1The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

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Consequences of Centrosome Dysfunction During Brain Development,sm disease Seckel syndrome (SCKS) and microcephalic osteodysplastic primordial dwarfism type II (MOPD-II) are often connected to mutations in centrosomal genes. In this chapter, we discuss the consequences of centrosome dysfunction during development and how they can contribute to the etiology of human diseases.

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The Elephant in the Room: The Role of Microtubules in Cancer,lar mechanisms that might alter microtubule dynamics in cancer cells, the pro and cons of the different theories linking these alterations to cancer progression, and the possible directions to address future key questions.