Titlebook: Cardiac Glycosides 1785–1985; Biochemistry — Pharm Erland Erdmann,K. Greef,J. C. Skou Conference proceedings 1986 Springer-Verlag Berlin He

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The “endogenous cardiac glycoside”ular Na.-concentration may also mediate hormonal effects on cellular processes (66). Provided this concept is right, the sodium pump must also be considered as a receptor of hormones and as a mediator of hormonal action (3). Alterations of the intracellular sodium concentration are considered to be

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Electrophysiological effects of cardiac glycosidesf s. r. function such as caffeine and ryanodine. As well as these oscillations of [Ca.]. which follow repolarization, there are also spontaneous oscillations in the absence of stimulation. These spontaneous oscillations, which also result from release of Ca from the sarcoplasmic reticulum, interfere

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Rat cardiac hypertrophy: contribution of heteregeneous digitalis receptor formsduced hypertrophied rat hearts working under isovolumic conditions in the presence of 0.25 mM [Ca]...Under these conditions, as compared to normal hearts, the inotropic response of hypertrophied hearts to ouabain appeared to be depressed and mainly prolonged. This delayed recovery of normal contract

HILAR

Digitalis receptors in normal and hypertrophied rat hearts. Differential effects of a Ca2+ free perfts. The pressure-overload induced hypertrophy represented a suitable model in that the movements of Ca. appeared to be slowed..When the heart was maintained at a physiological calcium level (2.5 mM), hypertrophied and normal cardiac preparations had heterogeneous ouabain binding sites: H. A. (K. 3 ×

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Biphasic contractile response to ouabain: Species specific? Calcium dependent? Altered sensitivity?onse to high ouabain concentrations was identical in both exposures. In Langendorff perfused rat heart preparations the “l(fā)ow-dose” response was not diminished by repeated ouabain exposure and .H-ouabain binding was not altered. The “l(fā)ow-dose” effect was not present in rat atrial strip preparations..