Titlebook: Cardiac Glycosides 1785–1985; Biochemistry — Pharm Erland Erdmann,K. Greef,J. C. Skou Conference proceedings 1986 Springer-Verlag Berlin He

清唱?jiǎng)?/a>

Ji?i Outrata,Michal Ko?vara,Jochem Zowesults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain re

解脫

Nonconvex Optimization and Its Applicationsase in porous and reconstituted human red blood cell ghosts. At low Mg., conformational changes become evident in the presence of various ligands which cannot be studied at physiological concentrations of Mg.. By using reconstituted human red cell ghosts containing ATP and little Mg., it is possible

MORPH

https://doi.org/10.1007/978-0-387-09653-7e molecular basis for the increased digitalis sensitivity of the conducting system. .H-ouabain binding has the following characteristics:.(1) in sheep left ventricular cell membranes, specific binding was of high affinity (K. 1.9 × 10.M at 37°); was coincident with an inhibition of (Na. + K.)-ATPase

Prophylaxis

Advances in Mechanics and Mathematicsce an initial prolongation of the action potential due to inhibition of the electrogenic Na-K pump current. This is then followed by a gradual decrease of action potential duration to less than control length. The origin of this decrease is uncertain. Cardiac glycosides also produce a transient depo

場(chǎng)所

Nonsmooth Equations in Optimizationum-sensitive microelectrodes, sodium pump activities could be described quantitatively in sheep heart Purkinje fibres. In the presence of cardiac steroids, partial sodium pump inhibition caused intracellular sodium to rise, thus presumably stimulating non-inhibited pumping sites. At the transition t

thwart

Parametric Optimization Problems,on by ouabain occurs in the same range of concentrations as pharmacologically active doses in various species including rat. In this species, it has been shown that the sensitivity of Na/K-ATPase to ouabain was heterogeneous with high and low sensitivity forms (K. 10., 10. M and 10., 10. M, respecti

GROUP

Cerebrovascular

Analysis of Generalized Derivatives,. ~ 0.3–0.5 .M, “high dose” effect ED. > 10 .M. The “l(fā)ow-dose” (high affinity?) effect was masked by high Ca. (2 mM) and emphasized in low Ca. (0.5 mM). The “l(fā)ow-dose” inotropic effect in rat ventricular strips was significantly diminished by repeated exposure to high ouabain concentrations as was .

Phenothiazines

直覺沒有