Titlebook: Cancer Therapy; Monoclonal Antibodie Hans G. Beger (Professor of Surgery),Markus Büchle Conference proceedings 1989 Springer-Verlag Berlin

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l chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-C

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J. I. Sprent,F. R. Minchin,R. Parsonsoned from the HUT 102 cell line, and using a yeast expression system, recombinant human GM-CSF (rhGM-CSF) has been produced and purified to homogeneity [4]. It has also been possible to clone rhGM-CSF from the human Mo-cell line [5].

健談的人

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Ceramic

CANDY

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Immunochemotherapy of Cancer: A Perspectiverly by applying immunoconjugates. Among these conjugates, those made between monoclonal antibodies and either chemotherapeutic drugs, radionuclides, or plant toxins represent the three major categories.

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Immunotherapy of Pancreatic Cancer with Monoclonal Antibody BW 494: Results from a Multicentric Phaspatients (0.4% with 5-year survival) were still alive [2]. Only about 10%–20% of the patients are able to undergo a potentially curative operation in the form of a partial or total pancreatoduodenectomy [1, 2, 6–9]. The therapeutic dilemma is further characterized by the lack of response to chemo- or radiotherapy [10–15].

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Interaction of Monoclonal Antibodies with Biological Response Modifiers and Cytostaticsdrug combinations tested result in similar response rates, (b) that second- or third-line therapy may be active even in the event of nonresponse in the first trial, and (c) that we do not have clinical parameters indicating tumor sensitivity or insensitivity before therapy is initiated.

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A. L?scher,K.B. Lauritsen,M. S?rensens, and we (Digel et al. 1988) have shown recently that recombinant TNF-α stimulates the growth of purified B cells from patients with B-chronic lymphocytic leukemia (B-CLL). Based on these findings, we hypothesize that TNF is produced in B-cell disorders like HCL and that TNF may stimulate the growth of hairy cells (HC).