Titlebook: Cancer Immunotherapy; Paradigms, Practice Tyler J. Curiel Book 2013 Springer Science+Business Media New York 2013 Anti-tumor immunity.Canc

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International Political Economy Series. In this chapter, we review and summarize current knowledge regarding the function, interactions, and prognostic significance of each of these populations, as well as their dependence upon one another within the tumor microenvironment.

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https://doi.org/10.1007/978-88-470-2571-4 the production of various intermediates such as reactive nitrogen species and reactive oxygen species that can suppress T cell function. Here, we review recent concepts on how MDSC can regulate T cell function in cancer and other chronic inflammatory diseases and suggest possible therapeutic interventions to overcome this inhibitory effect.

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Cytokines in the Treatment of Cancerdels. New strategies for improving the therapeutic benefit of cytokines are in development and include cytokine-antibody fusion molecules, delivery in recombinant viral vectors, expression by irradiated whole tumor cells, PEGylation, DNA vaccination, and ex vivo exposure to immune effector cells.